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This is followed by vomiting, diarrhoea, rash, symptoms of impaired kidney and liver function, and in some cases, both internal and external bleeding (e.g. Laboratory findings include low white blood cell and platelet counts and elevated liver enzymes.

Ebola virus is known to persist in immune-privileged sites in some people who have recovered from Ebola virus disease.

Relapse-symptomatic illness in someone who has recovered from EVD due to increased replication of the virus in a specific site is a rare event, but has been documented.

Reasons for this phenomenon are not yet fully understood.

An experimental Ebola vaccine proved highly protective against the deadly virus in a major trial in Guinea.

The vaccine, called r VSV-ZEBOV, was studied in a trial involving 11 841 people during 2015.

Community engagement is key to successfully controlling outbreaks.It can be difficult to clinically distinguish EVD from other infectious diseases such as malaria, typhoid fever and meningitis.Confirmation that symptoms are caused by Ebola virus infection are made using the following diagnostic methods: Careful consideration should be given to the selection of diagnostic tests, which take into account technical specifications, disease incidence and prevalence, and social and medical implications of test results.The latter occurred in a village near the Ebola River, from which the disease takes its name.The 2014–2016 outbreak in West Africa was the largest and most complex Ebola outbreak since the virus was first discovered in 1976.

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It is strongly recommended that diagnostic tests, which have undergone an independent and international evaluation, be considered for use.

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